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USCDI v6 and the Future of Interoperability

Healthcare interoperability continues to evolve with significant momentum. With USCDI v6 released, USCDI v3 becoming a regulatory requirement for certified health IT on January 1, 2026, and major EHR vendors racing to align their platforms, the industry is closer than ever to achieving truly seamless, patient-centered data exchange. For healthcare leaders planning new facilities or system upgrades, understanding these changes isn't optional, it's essential to building future-ready infrastructure.


The federal government's latest interoperability standard offers a roadmap for more connected care, adding new data elements that support clinical precision, public health, and care coordination. At the same time, leading EHR vendors are evolving their platforms to align with these standards, signaling a broader industry shift toward real-time, structured data exchange.

 

What Is USCDI?

Two hands each hold a white puzzle piece in front of a modern hospital building. The left puzzle piece reads “USCDI” and the right reads “INTEROPERABILITY,” symbolizing the connection between data standards and seamless health information exchange. Behind the puzzle pieces, blue hexagonal icons represent healthcare concepts such as a heart, medical documents, accessibility, and wireless connectivity, reinforcing the theme of digital health integration. Equinox HIT logo at bottom.

The United States Core Data for Interoperability (USCDI) is a standardized set of health data classes and elements developed by the Office of the National Coordinator for Health IT (ONC). It defines the minimum data that certified health IT systems must be capable of exchanging to support interoperability across care settings. USCDI is updated annually and serves as the foundation for ONC's Health IT Certification Program, Trusted Exchange Framework and Common Agreement (TEFCA) participation, and Fast Healthcare Interoperability Resources (FHIR)-based APIs (application programming interfaces that enable systems to exchange data).

To understand v6's significance, let's look at how we got here.

  • v1: 2020 — Foundation data classes

  • v2: 2021 — Health equity focus (SOGI, SDOH)

  • v3: July 2022 — Equity, disparities, public health (Required for certified health IT by January 1, 2026)

  • v4: July 2023 — Care planning, medication reconciliation

  • v5: July 2024 — Health equity & identity focus

Introduced 16 new data elements across 2 new data classes. These additions advance health equity, identity representation, and clinical precision.

New Data Classes:

  • Observations: Non-lab and non-imaging tests and findings

  • Orders: Includes medication, lab, imaging, and procedure orders

Notable Data Elements:

  • Name to Use

  • Pronouns

  • Sex Parameter for Clinical Use

  • Advance Directive Observation

  • Interpreter Needed

  • Medication Order

  • Author and Author Role

  • v6: July 2025 — Care planning & device tracking

Builds on v5 with a focus on care planning, device tracking, and facility-level data. These updates aim to improve longitudinal care, emergency preparedness, and public health surveillance.

Promoted Data Elements:

  • Care Plan

  • Unique Device Identifier

  • Family Health History

New Data Elements:

  • Facility Address

  • Date of Onset

  • Device Used

Updated Elements:

  • Vaccine Code (renamed from "Immunizations")

  • v7: In development — Draft expected January 2026, final July 2026

The ONC has confirmed that USCDI v7 is already in progress, with public submissions for new data elements underway. Early proposals include additions related to protective factors, social programs, and expanded terminology standards.

 

Vendor Landscape: USCDI Adoption

Standards are only as good as their adoption. Here's how the major EHR vendors are responding:

Epic Systems

Latest innovations: MyChart Central for unified patient access, Bluetooth sensor integration, real-time wayfinding, staff duress alerts, and prior authorization APIs

USCDI alignment: USCDI v3 support available; actively developing v5 support

QHIN status: Epic Nexus, a subsidiary of Epic, obtained Qualified Health Information Network (QHIN) status in 2023

Oracle Health (Formerly Cerner)

Platform evolution: AI-first solutions with FHIR-based interoperability

USCDI alignment: Supports FHIR R4 APIs for standards-based exchange with USCDI compliance QHIN status: Achieved candidate status (working toward full designation)

MEDITECH

Platform focus: Intelligent data usability and clinician-friendly interoperability through Expanse platform

USCDI alignment: Full support of USCDI v4; committed to v5 support in 2025

QHIN connectivity: Partnered with Health Gorilla (designated QHIN) through Traverse Exchange network

Veradigm (Formerly Allscripts)

Platform approach: Provider-payer-life sciences connectivity through the Veradigm Network

USCDI alignment: Supports FHIR R4 APIs with USCDI compliance across TouchWorks and Altera platforms

QHIN connectivity: Partnered with MedAllies (designated QHIN)

 

Why This Matters: Interoperability vs. Integration

Here's a distinction that matters for every healthcare construction project: integration connects systems; interoperability ensures they actually understand each other. In August, we explored the distinction between interoperability and integration in HIT, a critical nuance for healthcare leaders. USCDI v6 pushes the industry past simple data exchange toward true semantic interoperability. This means a care plan documented in one system is immediately understood and actionable in another, without translation or manual intervention. This isn't just a technical achievement. It's a transformation in how care is delivered across organizational boundaries. Standardized data elements enable seamless, meaningful exchange across platforms and care settings, turning fragmented information into coordinated care.

 

Ready to Build for Tomorrow's Standards Today? Equinox HIT is Your HIT Construction Partner.

Man in hard hat and glasses uses a tablet at a construction site. Background shows a building and cranes under a clear blue sky.

At Equinox HIT, we ensure your healthcare construction project isn't just compliant. It's built to excel as interoperability standards evolve. Whether you're deploying Epic, Oracle Health, MEDITECH, Veradigm, or another platform, we translate federal standards like USCDI v6 into actionable strategies that work in your facility from day one.

Our expertise spans:

  • Clinical workflow mapping aligned with USCDI data elements

  • Device deployment strategies for seamless EHR integration

  • Governance frameworks that support long-term scalability

  • C-suite technology roadmaps that bridge construction and activation


Don't let your technology infrastructure become obsolete before the ribbon cutting. From device deployment to C-suite alignment, we ensure technology isn't just installed. It's activated with purpose.

Contact us today to learn how we can help you build smarter, more connected spaces, ready for the future of care and compliant with tomorrow's standards.


References:

  1. AHIMA. "What Does the TEFCA Mean for Your Organization?" 2025. Link

  2. Becker's Hospital Review. "EHR vendors step up interoperability efforts." 2024. Link

  3. Becker's Hospital Review. "Epic unveils new interoperability features: 7 things to know." 2025. Link

  4. Becker's Hospital Review. "Hospitals Accelerate EHR Upgrades in 2025." 2025. Link

  5. eCQI Resource Center. "USCDI v6 Available Now." 2025. Link

  6. EHR Association. "Comments on USCDI v6 Draft." 2025. Link

  7. Epic Systems. "Epic's FHIR API Specifications." 2025. Link

  8. Epic Systems. "In latest interoperability expansion, Epic advances personalized care." 2024. Link

  9. Epic Systems. "Open. Epic: USCDI v5 Development." 2025. Link

  10. Equinox HIT. "Interoperability vs. Integration in HIT." 2025. Link

  11. HCI Innovation Group. "ASTP Releases New Version of USCDI." 2025. Link

  12. MEDITECH. "MEDITECH advances interoperability standards with its full support of USCDI v4." 2025. Link

  13. MEDITECH. "The Push and the Pull: An Interoperability Update." 2024. Link

  14. Oracle Health. "2025 Cerner Real World Testing Plan." 2025. Link

  15. TechTarget. "ONC releases USCDI Version 5 to drive interoperability." 2024. Link

  16. U.S. Department of Health and Human Services. "Health Data, Technology, and Interoperability: Certification Program Updates, Algorithm Transparency, and Information Sharing (HTI-1) Final Rule." 2023. Link

  17. Veradigm. "Introduction - Veradigm and Altera FHIR API." 2025. Link

 

This article was developed by the Equinox HIT Team with editorial assistance from AI tools and re-reviewed by the Equinox HIT Team for accuracy and alignment with our standards.

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